Moneyline: Padres -170, Diamondbacks +150 Moneyline: Angels -135, Astros +115 Padres vs. Moneyline: Braves -210, Reds +175 Astros vs. Moneyline: Cardinals -220, Pirates +180 Reds vs. Moneyline: Guardians -125, Royals +105 Pirates vs. Moneyline: Brewers -170, Cubs +150 Guardians vs. MLB Opening Day odds on DraftKings Sportsbook Brewers vs. Here’s a look at the odds for each matchup on Opening Day for the 2022 MLB season. is favored (-135) versus the defending American League champs. Opening Day’s marquee matchup features the Houston Astros taking on Shohei Ohtani, Mike Trout and the Los Angeles Angels. Louis Cardinals are the day’s biggest favorite (-220) as they will host the Pittsburgh Pirates. The Braves are heavy favorites (-210), but the St. The defending World Series champion Atlanta Braves will open up at home versus the Cincinnati Reds. Twins - leaving us with seven games on Thursday’s slate. Two games have already been postponed - Red Sox vs. MLB’s 2022 Opening Day is finally here! A little later than originally expected! And with fewer games than originally scheduled! But hey, it’s still here.
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